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Nanosponges: A Rapid Haemostatic Material


Author: K.Dhanavardhini, Research Scholar, Centre for Nanotechnology Research (CNR), VIT, Vellore.


Nanosponges, at first glance, might sound like something out of a captivating science fiction tale – microscopic sponges with an extraordinary talent for carrying and precisely delivering medications. These tiny wonders measure a mere 250 nm to 1 μm in size and boast a structural backbone made of polyester, creating a three-dimensional network through a solution combined with cross linkers.


A Marvelous Haemostatic Solution

What truly sets nanosponges apart in the realm of drug delivery is their phenomenal stability as a nanosized delivery technology. They possess an impressive ability to accommodate both hydrophilic and hydrophobic molecules, showcasing a large carrier capacity without any harmful effects. In addition, nanosponges are equipped to target specific bodily spots with utmost precision, controlling release rates and enabling the controlled release of topical drugs at specific regions for over four hours.


Hemostasis is the process of stopping bleeding and keeping blood in a damaged blood vessel. It's the first step in wound healing. Hemostasis involves coagulation, which changes blood from a liquid to a gel.

X-ray trackers a magical twist

But the intrigue doesn't end there. Nanosponges ability to be tracked using X-rays adds a remarkable layer to their tale. This makes them an invaluable asset in the realm of medicine, allowing healthcare professionals to monitor their journey through the body, ensuring the accurate delivery of medications.


Figure. Nanosponges as a Haemostatic material - work flow


The Endurance of Nanosponge Legend

In the grand narrative of medicine, nanosponges have emerged as true game-changers. Their potential to revolutionize targeted treatments and minimize the side effects of medications is awe-inspiring. They stand as a testament to the ingenuity of modern science and hold the promise of transforming the future of drug delivery.


"Nanosponges: Tiny heroes staunching the flow, turning bleeding into healing's glow."

As we continue to unravel the potential of these microscopic heroes, it becomes clear that nanosponges are leading us into a future where drug delivery is not just effective, but also incredibly precise. The tale of nanosponges is one of innovation, hope, and the boundless possibilities for a healthier, more targeted approach to medical treatment.


References:

1. Patel, E. K., & Oswal, R. J. (2012). Nanosponge and micro sponges: a novel drug delivery system. Int J Res Pharm Chem, 2(2), 237-244.


2. Patel, S. B., Patel, H. J., & Seth, A. K. (2010). Microsponge drug delivery system: an

overview. Journal of Global Pharma Technology, 2(8), 1-9.


3. Cavalli, R., Trotta, F., & Tumiatti, W. (2006). Cyclodextrin-based nanosponges for drugdelivery. Journal of inclusion phenomena and macrocyclic chemistry, 56(1-2), 209-213.




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